The earlier the disease is detected, the better the prospects for a patient.

Researchers have developed a new blood test that may detect certain types of cancer up to four years before the first symptoms appear. It is a promising test. Because it means that the chance of survival is a lot bigger.

PanSeer
The new blood test, called PanSeer and published in the journal Nature , is not a very drastic treatment. But its potential is great. The test can accurately reveal five common types of cancer – namely gastric, esophageal, colon, lung and liver cancer – at a very early stage. “People often don’t go to the doctor until the symptoms are clear or severe enough,” researcher Kun Zhang tells Scientias.nl . “But tumor growth is likely to occur long before it is noticed.”

Study
In the study, the researchers performed the blood test on 605 asymptomatic individuals. Later, 191 of them were diagnosed with cancer. The PanSeer test correctly and in some cases even four years before the actual diagnosis detected the five types of cancer mentioned in 91 percent of cases. The researchers emphasize that the test therefore does not predict who will develop cancer later. These people probably already had a degree of cancer growth but did not yet have the associated complaints.

Survival Chances
The test can therefore detect a wide range of cancers successfully and at a very early stage. And that is encouraging. “It greatly increases the chances of survival,” says Zhang. Because if the disease is detected at an early stage, a tumor can soon be removed surgically or treated with medicines. And that means that the outlook for a patient is a lot better.

Method
How is it possible that the test can detect cancer so early? “In the body, some tumor cells can die for various reasons,” Zhang explains when asked. “For example, when there is a lack of nutrients, or if they are attacked by our immune system. When they die, these cells release their DNA and some of that DNA ends up in the blood. By capturing and identifying such DNA molecules, cancer can therefore be detected at an early stage. ”

Other cancers
At this time, the promising blood test focuses only on stomach, esophagus, colon, lung and liver cancers. But it may not stop there. “We have pre-compiled a list of 500 cancer-specific signatures in terms of DNA methylation or chemical modification of the DNA,” said Zhang. “We then looked specifically for such signs in the blood. This is why the blood test can detect the five types of cancer mentioned. However, PanSeer can also detect other cancers simply by looking for signatures specific to the type of cancer of interest. ”

Other blood tests

PanSeer is not the first test to reveal cancer through the blood. Researchers had previously developed a revolutionary test that detected as many as 50 types of cancer well before people developed symptoms . In addition, thanks to the blood test, doctors can gain insight into where the tumor is located in the patient’s body. There is also a blood test that can detect mutations as well as proteins associated with eight different and common cancers, and one that points to early detection of skin cancer . They are all promising treatments that will ensure that far fewer people will die of cancer.

Routine
The ultimate goal is to routinely perform such blood tests during annual health checks. But whether that will actually happen is the question. It is probably very expensive to screen everyone regularly. Therefore, people at higher risk should be tested primarily, for example based on family history, age or other known risk factors.

Although PanSeer has successfully passed the first fire test, we are not there yet. Indeed, more research is needed to confirm the test’s ability to detect cancers at an early stage. “It will take at least another three to five years before the test can actually be used regularly in hospitals,” says Zhang. In any case, the first results are promising. In addition, it means that hopefully in the future, cancer will become a disease that is faster and more treatable. “I was surprised at how strong cancer-specific signatures are,” says Zhang. “If you only know what to look for.”

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